Best Lion’s Mane Supplement [2024]: Reviews and Ultimate Guide

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Best Lion’s Mane Supplement

Best of the Best
Host Defense Lion’s Mane
Runner Up
Four Sigmatic Lion’s Mane
Best Powder
Terrasoul Superfoods Organic Lion’s Mane
Host Defense, Lion's Mane Capsules, Promotes Mental Clarity, Focus and Memory, Mushroom Supplement, Unflavored, 60
Four Sigmatic Lion's Mane Mushroom Elixir | Coffee Alternative with Organic Lion's Mane Mushroom Powder, Rhodiola & Rose Hips | Immune & Memory Support | Paleo | Pack of 20
Terrasoul Superfoods Organic Lion's Mane Mushroom Powder (4:1 Extract), 5.5 Ounces
Best of the Best
Host Defense Lion’s Mane
Host Defense, Lion's Mane Capsules, Promotes Mental Clarity, Focus and Memory, Mushroom Supplement, Unflavored, 60
Runner Up
Four Sigmatic Lion’s Mane
Four Sigmatic Lion's Mane Mushroom Elixir | Coffee Alternative with Organic Lion's Mane Mushroom Powder, Rhodiola & Rose Hips | Immune & Memory Support | Paleo | Pack of 20
Best Powder
Terrasoul Superfoods Organic Lion’s Mane
Terrasoul Superfoods Organic Lion's Mane Mushroom Powder (4:1 Extract), 5.5 Ounces

Lion’s mane mushrooms, which lend themselves to the popular health supplement, bear a striking resemblance to the mane of the wild African cat. Now the name makes more sense!

Like many varieties of mushrooms, the lion’s mane variety has been used in certain Asian countries for hundreds of years both in cooking and in medicine.

You can take lion’s mane as a supplement in many ways, and the benefits range from relieving symptoms of anxiety and depression to boosting brain function.

Let’s dive right into our top picks for best lion’s mane supplement.

👑 Our Pick for Best Overall

Host Defense Lion’s Mane
11,527 Reviews
Host Defense Lion’s Mane
Host Defense’s memory and nerve support supplement does a great job of boosting mental clarity and helping clear up brain fog.

Our Other Top Lion’s Mane Supplement Picks

Best Lion’s Mane Supplement Reviews

Host Defense Lion’s Mane (⭐ Best of the Best)

The best lion’s mane supplement has to be Host Defense’s supplement, which is widely praised as an aid for memory and nerve support.

Host Defense is widely regarded as one of the best mushroom supplement brands, and it is praised for how well it harnesses the essence of each type of mushroom in its health supplement range. This lion’s mane supplement is geared towards memory and nerve support, and comes in the form of either 30, 60, or 120 capsules. These capsules are to be taken twice daily, and don’t require you to have a full stomach so you can take them whenever is best for you.

The main benefits which this lion’s mane supplement boasts are enhanced mental clarity, boosted focus, and improved memory. In other words, by taking this supplement on a daily basis you can aid cognition and help protect the brain from degeneration in the form of memory loss. The supplement can also give your immune system a boost, so in line with the brand name, this product can improve your body’s defenses in a variety of ways.

As a vegetarian capsule, you can take this supplement at your convenience, which makes it a popular option for those with a busy or active lifestyle. The mushrooms are sustainably cultivated, Certified Organic, and grown in the U.S.


  •  Available as 30, 60, or 120 capsule pack
  •  Certified Organic, sustainably sourced mushrooms
  •  Grown in U.S.
  •  Vegetarian and vegan-friendly

Four Sigmatic Lion’s Mane (🥈 Runner Up)

Four Sigmatic’s lion’s mane Elixir Mix is a powder with rhodiola and rose hips, which compliment the benefits of the mushroom extract. 

Four Sigmatic have taken a novel approach to presenting lion’s mane, by throwing in other healthy ingredients and combining it all into an easy to mix powder. This isn’t your average supplement powder though, no, this Elixir Mix is designed not to taste horrible and can be mixed into anything from coffee to smoothies. Given that mushrooms can have very earthy, slightly off putting flavors when it comes to supplementing with them, this easy to mix powder makes the process much more pleasant.

This lion’s mane supplement is aptly named ‘Think’, and it is meant to boost productivity and focus levels, which leverages the nootropic qualities of the mushroom type. If you suffer from brain fog while you study or try to get work done through the day, then all you need to do is brew some hot tea or coffee and add this Elixir Mix for a cognitive boost. Better yet, if you want to steer clear of caffeine for whatever reason, you can add this mix to a delicious smoothie and still get the brain boosting benefits.

The fact that the lion’s mane mushroom extract used in this powder is made from wood-grown fruiting bodies is encouraging, as it means the brand has gone the extra mile to use the best of the mushroom. This is as opposed to many other brands which use filler ingredients like brown rice in their mushroom supplements. As for the other ingredients, the addition of rose hips provides you with a healthy dose of vitamin C while the organic rhodiola can help boost productivity. The mint is there as a way of ensuring the flavor stays fresh and keeps you coming back for more.

This supplement is vegan-friendly, suitable for the keto diet, and free from dairy and gluten. You’ll find nothing but natural ingredients in this powder, which means no artificial flavours or fillers. 


  •  Pack of 20 
  •  Each pack has 1500mg of organic lion’s mane mushroom extract
  •  Includes rose hips, rhodiola, and mint
  •  All-natural ingredients
  •  Suitable for vegans, keto, and free from dairy and gluten 
  •  Easy to mix
Four Sigmatic Lion’s Mane
3,573 Reviews
Four Sigmatic Lion’s Mane
This lion’s mane powdered supplement from Four Sigmatic is one of the best ways of taking the mushroom extract. It’s a palatable blend that can clear brain fog and boost cognitive function when you most need it.

Terrasoul Superfoods Organic Lion’s Mane (💯 Best Powder)

Terrasoul Superfoods’ Organic lion’s mane is the best powdered form of the mushroom supplement in our view.

This lion’s mane supplement is made using a highly concentrated extract of the mushroom, and nothing else. If you want a high dose of the highly beneficial mushroom, then this is one of the best ways to get it. While taking lion’s mane in capsule form might be more convenient, taking it in a highly concentrated powder like this one will give you greater control over the dose and greater benefits.

Each batch of this powder is tested in the lab, and Terrasoul boasts a 4:1 ratio for the extract powder, which is best for both digestibility and potency. Many happy customers have reported the benefits from taking this powdered supplement on a regular basis. One user even referred to it as one of the most powerful nootropics that they’ve come across. Boosted cognitive function is one of the primary reasons many people decide to supplement lion’s mane, and on the evidence of an overwhelming number of positive reviews, this powder does just that.

There’s a 100% money-back satisfaction guarantee for this supplement too, which should make the investment seem less risky.


  •  5.5 oz packet 
  •  4:1 lion’s mane mushroom extract powder 
  •  USDA Certified Organic, non-GMO, gluten-free, vegan
  •  100% money-back guarantee
Terrasoul Superfoods Organic Lion’s Mane
896 Reviews
Terrasoul Superfoods Organic Lion’s Mane
Terrasoul Superfoods provides a highly concentrated powdered form of lion’s mane extract, which is the best way to get your fix whenever you need it.

Ultimate Guide to Lion’s Mane Supplementation

Lion’s mane mushroom is a great ingredient for a health supplement, and in this guide you’ll find out why you should consider using it.

Alleviate Symptoms of Anxiety and Depression

Taking lion’s mane in supplement form can help you deal with anxiety or depression symptoms, and reduce their severity.

Given the growing prevalence of anxiety disorders and depression, finding a natural health supplement that could help alleviate symptoms may come as a great relief.

While of course lion’s mane won’t make all of your symptoms go away, its anti-inflammatory properties can reduce certain symptoms.

It has also been shown to boost the hippocampus region of the brain, which takes care of emotional responses. This protection in the brain can help the body defend against neurological-based symptoms.

Boost Brain Function

Lion’s mane supplements are most well-known for their brain-boosting benefits, which range from enhanced mental clarity to protection against dementia.

These mushrooms are often used in nootropics, the brain enhancing supplements, since they have been shown to stimulate brain cell growth.

They can also potentially help prevent memory loss too, which makes it a good supplement to take to fight against cognitive decline.

Aid Nervous System Recovery

Lion’s mane supplements not only help boost brain function, but they can also help with the body’s nervous system.

Much like the lion’s mane mushrooms can accelerate the growth of brain cells, they can also stimulate the growth of nerve cells.

That makes them great for aiding recovery in nervous system-related injuries.

Improves Immune System

The immune system is incredibly important for keeping you healthy and fighting off sickness, so any help you can give it is well worth your time.

By aiding the intestinal immune system, lion’s mane can help protect the body against bacteria and potentially keep you healthy and better able to defend against sickness.

Works as Anti-Inflammatory

Lion’s mane mushrooms have anti-inflammatory properties which can help the body deal with a lot of diseases caused by inflammation such as autoimmune disorders and cancer.

This is one of the mushrooms biggest benefits, and as this type of mushroom has one of the highest amounts of antioxidants in any mushroom species.

Much like the immune system boost, the anti-inflammatory benefits of lion’s mane are huge for ensuring you stay healthy and your body stays in great shape.

Related: Best Reishi Supplement

Frequently Asked Questions About Lion’s Mane

What is the best way to take lion’s mane?

There are a variety of ways to take lion’s mane, such as raw, cooked, or in a hot drink like tea or coffee.

Generally though, the best way to take lion’s mane is as an extract. The extract takes the best parts of the mushroom and distills them down to make it easy to take without eating plates of mushrooms.

This extract is found most commonly in the form of capsules or powders, and there are benefits and drawbacks to taking it in both forms.

Does lion’s mane really work?

Yes, lion’s mane supplements have been researched and studies have shown that they can provide numerous health benefits.

Lion’s mane is commonly used in cognitive boosting nootropics, since they can improve brain function.

It’s also taken by a lot of people who suffer with anxiety and/or depression. With anti-inflammatory properties and an ability to boost the hippocampus region of the brain, lion’s mane can reduce the severity of some symptoms of depression and anxiety.

How much lion’s mane should I take daily?

The amount you take lion’s mane will vary based on the exact supplement. 

While nootropics will have certain recommendations for what the daily dose should be, powdered supplements might suggest different quantities.

Always make sure you read the label of the supplement before you start taking it to ensure you get the correct dose.

Related: Best Cordyceps Supplement

A Final Word from Energetic Lifestyle

Lion’s mane mushrooms make for fantastic health supplements, given their potential neuroprotective and anxiety-reducing benefits.

Once you figure out how you want to take the supplement, select based on what exactly you want from it and what past customers have to say about its efficacy.

This post may contain affiliate links. Please read our disclosure for more info.
Article by:

Energetic Lifestyle Team

Our detailed review has been contributed to by multiple members of the Energetic Lifestyle Review Team to ensure the best research and highest standard of quality. Have a good or a bad experience with one of the products? Please let us know, we love the feedback!
  • Jenny says:

    Hi, do you recommend buying mushroom extract powder over capsules? If so, where do you buy them?

    • Energetic Lifestyle Team says:

      Definitely not a bad option! You can usually find the extracts at health food stores or Asian markets. If you’re near a Whole Foods, you can try there as well.

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